Bus Tickets from Chicago to Florence, SC, US

Previously seen trips

Next departures for Chicago to Florence on October 8
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound + FlixBus
537-517 W. Jackson Blvd
Florence, SCNo tags
FlixBus + Greyhound
Downtown Greyhound Station
Florence, SCNo tags
Greyhound + FlixBus
Chicago 95Th & Dan Ryan
Florence, SCNo tags
FlixBus + Greyhound
Chicago 95Th & Dan Ryan
Florence, SCNo tags
Greyhound + FlixBus
Downtown Greyhound Station
Florence, SCNo tags

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Compare 2 ways to go from Chicago to Florence.

Bus
Average Price$98 - $207Average Duration1d 6h
27kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$186 - $427Average Duration1d 7h
100kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the bus from Chicago to Florence

Among the sustainable travel choices, the bus stands out as the good way to reach Florence. The journey takes about 1 day, 6 hours 15 minutes and with fares starting at just $98, it presents an excellent value for a comfortable ride.

4bus per day
1d 6hAverage Duration
$98Cheapest ticket
27kgCO₂ emissions

Bus Chicago to Florence, SC, US: Trip Overview

Average ticket price$142
Average bus trip duration1d 6h
Number of daily buses4
Earliest bus departure10:00am
Distance672 miles (1083 km)
Latest bus departure11:15pm

Chicago to Florence Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Chicago to Florence.

Bus service from Chicago to Florence will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Chicago, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Chicago - Florence, SC, US

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/05
No data
10/06
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Today
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10/08
$15
10/09
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10/10
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10/11
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10/12
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busbud logoThe cheapest trip from Chicago to Florence, SC, US was searched and found on Oct 8, 2025 with a price of $15

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Florence, SC, US, as early as possible.

You can expect to pay from $15 to $22 for a bus ticket from Chicago to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at $15 which is on 2025-10-08.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Chicago to Florence but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Chicago to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Chicago to Florence.

Make a music playlist for your bus ride from Chicago to Florence, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

What's the cheapest way to go from Chicago to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Chicago by bus?

Bus from Florence, SC, US to Chicago

You can also go to Florence, SC, US by train

Train from Chicago to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

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