Bus Tickets from Detroit, MI to Knoxville, TN

Next departures

Next departures for Detroit to Knoxville on October 22
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Detroit Bus Station
Knoxville Bus StationCheapest
Greyhound Lines, Inc.
Detroit Bus Station
Knoxville Bus StationFastest
Greyhound Lines, Inc.
Detroit Bus Station
Knoxville Bus StationNo tags
Greyhound Lines, Inc.
Detroit Bus Station
Knoxville Bus StationNo tags

Last refresh of the prices: Yesterday at 2:30 PM EDT.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Bus Detroit, MI to Knoxville, TN: Trip Overview

Average ticket price$71
Average bus trip duration21h 45m
Number of daily buses4
Earliest bus departure6:40am
Distance439 miles (707 km)
Latest bus departure11:25pm

Detroit to Knoxville Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Detroit to Knoxville.

We make it our job to connect you with the most dependable bus companies that cover bus service from Detroit to Knoxville.

From cheap bus tickets to more luxurious buses traveling from Detroit to Knoxville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Detroit, MI - Knoxville, TN

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/20
$84
10/21
$77
Today
$81
10/23
No data
10/24
$70
10/25
$57
10/26
$54
10/27
$42
busbud logoThe cheapest trip from Detroit, MI to Knoxville, TN was searched and found on Oct 27, 2025 with a price of $42

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Knoxville, TN, as early as possible.

You can expect to pay from $42 to $129 for a bus ticket from Detroit, MI to Knoxville, TN based on the last 2 days. You can expect to find the cheapest price for the trip at $42 which is on 2025-10-27.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Detroit to Knoxville but it'll also be endearing to native speakers who will surely appreciate your effort.

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Detroit to Knoxville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Detroit to Knoxville that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Detroit to Knoxville while indulging in miles on end of beautiful scenic views.

Did you know?

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Detroit, MI by bus?

Bus from Knoxville, TN to Detroit, MI

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Detroit

Buses Leaving from Detroit

Buses Going to Detroit

Popular Buses Connecting Knoxville

Buses Leaving from Knoxville

Buses Going to Knoxville