Bus Tickets from La Crosse, WI to Chicago

Next departures

Next departures for La Crosse to Chicago on October 11
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Jefferson Lines
La Crosse MTU Transit Center
Chicago (Bus Station)CheapestFastest
Jefferson Lines
632 17th Street North
Chicago (Bus Station)No tags

Last refresh of the prices: Today at 1:44 PM CDT.

Accepted payments

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Compare 2 ways to go from La Crosse to Chicago.

Bus
Average Price$184 - $184Average Duration17h 15m
9kg CO₂e5 out of 5 stars
Most eco-friendly
Train
Average Price$34 - $149Average Duration5h 8m
33kg CO₂e1 out of 5 stars
CheapestFastest
busbud logoBusbud recommends taking the train from La Crosse to Chicago

Among the sustainable travel choices, the train stands out as the good way to reach Chicago. The journey takes about 5 hours 8 minutes and with fares starting at just $34, it presents an excellent value for a comfortable ride.

3train per day
5h 8mAverage Duration
$34Cheapest ticket
33kgCO₂ emissions

Bus La Crosse, WI to Chicago: Trip Overview

Average ticket price$184
Average bus trip duration17h 15m
Number of daily buses2
Earliest bus departure12:25pm
Distance226 miles (364 km)
Latest bus departure12:50pm

La Crosse to Chicago Bus

Busbud helps you find a bus from La Crosse to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from La Crosse to Chicago from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Chicago from La Crosse, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip La Crosse, WI - Chicago

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/05
No data
10/06
No data
Today
$179
10/08
No data
10/09
$41
10/10
No data
10/11
$179
10/12
$179
busbud logoThe cheapest trip from La Crosse, WI to Chicago was searched and found on Oct 9, 2025 with a price of $41

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Chicago, as early as possible.

You can expect to pay from $41 to $179 for a bus ticket from La Crosse, WI to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $41 which is on 2025-10-09.

Usually Tornado Bus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between La Crosse and Chicago!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from La Crosse to Chicago, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from La Crosse to Chicago.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from La Crosse to Chicago.

Did you know?

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

You can also go to Chicago by train

Train from La Crosse, WI to Chicago

Why choose Busbud?

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