Bus Tickets from La Serena, CL to Antofagasta

Next departures

Next departures for La Serena to Antofagasta on October 14
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Andimar
La Serena (Bus terminal La Serena)
Terminal de Buses Cardenal Carlos Oviedo Cavada)Cheapest
Pullman San Andrés
Terminal de Buses La Serena
Terminal Carlos Oviedo CavadaFastest
Pullman San Andrés
Terminal de Buses La Serena
Terminal AntofagastaNo tags
Andimar
La Serena (Bus terminal La Serena)
Terminal de Buses Cardenal Carlos Oviedo Cavada)No tags
Cikbus Elité + Pluss Chile
Terminal de Buses La Serena
Terminal AntofagastaNo tags

Last refresh of the prices: Today at 4:07 PM -03.

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Bus La Serena, CL to Antofagasta: Trip Overview

Average ticket price$40
Average bus trip duration11h 35m
Number of daily buses30
Earliest bus departure12:05am
Distance438 miles (705 km)
Latest bus departure11:59pm

La Serena to Antofagasta Bus

Busbud helps you find a bus from La Serena to Antofagasta. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from La Serena to Antofagasta will be provided by the most trusted bus companies.

Whether it is cheap bus tickets or more luxurious buses going to Antofagasta from La Serena, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip La Serena, CL - Antofagasta

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/11
$33
10/12
$28
Today
$27
10/14
$27
10/15
$27
10/16
$20
10/17
$20
10/18
$27
busbud logoThe cheapest trip from La Serena, CL to Antofagasta was searched and found on Oct 17, 2025 with a price of $20

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena, CL to Antofagasta, as early as possible.

You can expect to pay from $20 to $53 for a bus ticket from La Serena, CL to Antofagasta based on the last 2 days. You can expect to find the cheapest price for the trip at $20 which is on 2025-10-17.

Usually Pullman San Andres, Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between La Serena and Antofagasta!

Much more than a mere vehicle taking you from La Serena to Antofagasta, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from La Serena to Antofagasta.

Make a music playlist for your bus ride from La Serena to Antofagasta, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

Will you be returning to La Serena, CL by bus?

Bus from Antofagasta to La Serena, CL

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Popular Buses Connecting Antofagasta

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