Bus Tickets from Port Saint Lucie to Gainesville, FL

Next departures

Next departures for Port Saint Lucie to Gainesville on October 8
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Port St. Lucie (Park & Ride)
Rosa Parks StationCheapest
FlixBus + Greyhound Lines, Inc.
Port St. Lucie (Park & Ride)
Gainesville Bus StopFastest
FlixBus
Port St. Lucie (Park & Ride)
Rosa Parks StationNo tags
FlixBus
Port St. Lucie (Park & Ride)
Rosa Parks StationNo tags

Last refresh of the prices: Yesterday at 4:52 AM EDT.

Accepted payments

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Bus Port Saint Lucie to Gainesville, FL: Trip Overview

Average ticket price$46
Average bus trip duration7h 40m
Number of daily buses3
Earliest bus departure1:40am
Distance206 miles (332 km)
Latest bus departure3:45pm

Port Saint Lucie to Gainesville Bus

Busbud helps you find a bus from Port Saint Lucie to Gainesville. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Port Saint Lucie to Gainesville.

From cheap bus tickets to more luxurious buses traveling from Port Saint Lucie to Gainesville, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip Port Saint Lucie - Gainesville, FL

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/05
No data
10/06
$65
Today
$62
10/08
$46
10/09
$52
10/10
No data
10/11
No data
10/12
No data
busbud logoThe cheapest trip from Port Saint Lucie to Gainesville, FL was searched and found on Oct 8, 2025 with a price of $46

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Gainesville, FL, as early as possible.

You can expect to pay from $46 to $65 for a bus ticket from Port Saint Lucie to Gainesville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $46 which is on 2025-10-08.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Port Saint Lucie and Gainesville!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you're bound to be in for a visual treat on your bus trip from Port Saint Lucie to Gainesville.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Port Saint Lucie to Gainesville that are otherwise impossible to come by with a plane.

Make a music playlist for your bus ride from Port Saint Lucie to Gainesville, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

The Superbus, created by a Dutch engineer is the world's fastest bus with 250 km/h. Too bad it's only a prototype for now.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to Port Saint Lucie by bus?

Bus from Gainesville, FL to Port Saint Lucie

Why choose Busbud?

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