Bus Tickets from Prague to Lyon

Next departures

Next departures for Prague to Lyon on October 6
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Flixbus
Prague (Central Bus Station Florenc)
PerracheCheapest
Flixbus
Prague (Na Knížecí)
PerracheFastest
Flixbus
Prague (Central Bus Station Florenc)
PerracheNo tags
Flixbus
Prague (Central Bus Station Florenc)
PerracheNo tags
Flixbus
Prague (Central Bus Station Florenc)
PerracheNo tags

Last refresh of the prices: Today at 2:27 PM CEST.

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Bus Prague to Lyon: Trip Overview

Average ticket price$78
Average bus trip duration19h 5m
Number of daily buses9
Earliest bus departure12:10am
Distance533 miles (859 km)
Latest bus departure11:50pm

Prague to Lyon Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Prague to Lyon.

We make sure you can find a bus service from Prague to Lyon from the most reliable bus companies operating this trip.

Whether it is cheap bus tickets or more luxurious buses going to Lyon from Prague, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions for your trip Prague - Lyon

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/03
No data
10/04
$61
Today
$73
10/06
$70
10/07
No data
10/08
$58
10/09
$58
10/10
No data
busbud logoThe cheapest trip from Prague to Lyon was searched and found on Oct 8, 2025 with a price of $58

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Prague to Lyon, as early as possible.

You can expect to pay from $58 to $128 for a bus ticket from Prague to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $58 which is on 2025-10-08.

Usually RegioJet will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Prague to Lyon but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from Prague to Lyon, get comfy and count the stars.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Prague to Lyon.

Tune out to the fine sounds of your best music playlist on your bus trip from Prague to Lyon while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

Will you be returning to Prague by bus?

Bus from Lyon to Prague

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