Bus Tickets from San Diego, CA, US to Indianapolis

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TodayJul 4
TomorrowJul 5
SunJul 6
from $207
MonJul 7
TueJul 8
WedJul 9
ThuJul 10
FriJul 11

Cheap buses leaving Sunday

One passenger / one way

  • This trip is recommended because it is: Cheapest
    Departure time: July 6 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: July 9 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • This trip is recommended because it is: Fastest
    Departure time: July 6 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: July 8 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 6 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: July 8 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 6 at
    Departure city: San Diego
    Departure location: Greyhound Bus Stop
    Arrival time: July 8 at
    Destination city: Indianapolis
    Destination location: Indianapolis Bus Station
    Operated by: Greyhound Lines, Inc.Greyhound Lines, Inc.
    Vehicle: BusDuration:
  • Departure time: July 6 at
    Departure city: San Diego
    Departure location: San Diego (Old Town-FlixBus)
    Arrival time: July 8 at
    Destination city: Indianapolis
    Destination location: Downtown Transit Center
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

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Compare 2 ways to go from San Diego to Indianapolis.

Bus
Average Price$207 - $574Average Duration2d 9h
72kg CO₂e5 out of 5 stars
CheapestFastestMost eco-friendly
Train
Average Price$208 - $542Average Duration2d 9h
261kg CO₂e1 out of 5 stars
busbud logoBusbud recommends taking the train from San Diego to Indianapolis

Among the sustainable travel choices, the train stands out as the good way to reach Indianapolis. The journey takes about 2 days, 9 hours 45 minutes and with fares starting at just $208, it presents an excellent value for a comfortable ride.

6train per day
2d 9hAverage Duration
$208Cheapest ticket
261kgCO₂ emissions

Bus San Diego to Indianapolis: Trip Overview

Average ticket price$346
Average bus trip duration2d 9h
Number of daily buses19
Earliest bus departure7:15am
Distance1776 miles (2863 km)
Latest bus departure7:35pm

San Diego to Indianapolis Bus

Busbud helps you find a bus from San Diego to Indianapolis. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make sure you can find a bus service from San Diego to Indianapolis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses traveling from San Diego to Indianapolis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions for your trip San Diego, CA, US - Indianapolis

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07/02
No data
07/03
No data
Today
$108
07/05
No data
07/06
$215
07/07
No data
07/08
$124
07/09
No data
busbud logoThe cheapest trip from San Diego to Indianapolis was searched and found on Jul 4, 2025 with a price of $108

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego to Indianapolis, as early as possible.

You can expect to pay from $108 to $271 for a bus ticket from San Diego to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at $124 which is on 2025-07-08.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and Indianapolis!

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to Indianapolis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Indianapolis that are otherwise impossible to come by with a plane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Indianapolis.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travelers have used their electronic device on board during 2014.

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

Will you be returning to San Diego by bus?

Bus from San Diego to Indianapolis

You can also go to Indianapolis by train

Train from San Diego to Indianapolis

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worldwide scale with our comprehensive list of bus routes and schedules. With several language and currency options available, Busbud seeks to cater to international bus travelers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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