Bus Tickets from Wilmington, DE to Florence, SC, US

Find affordable bus tickets from Wilmington, DE to Florence, SC, US with flexible options. Book your trip now

Join 75M+ travelers booking 2M+ routes across 85+ countries.
Enjoy our 24/7 customer service to assist you at every step.
Cancel anytime and receive a 100% refund, no reason needed.
ThuJul 24
FriJul 25
from US$74
SatJul 26
SunJul 27
MonJul 28
from US$71
TueJul 29
WedJul 30
ThuJul 31

Cheap buses leaving Friday

One passenger / one way

  • This trip is recommended because it is the: Cheapest
    Departure time: July 25 at
    Departure city: Wilmington
    Departure location: Wilmington Bus Station
    Arrival time: July 26 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • This trip is recommended because it is the: Fastest
    Departure time: July 25 at
    Departure city: Wilmington
    Departure location: Newark (DE)
    Arrival time: July 26 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: July 25 at
    Departure city: Wilmington
    Departure location: Wilmington Bus Station
    Arrival time: July 26 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: Greyhound Lines, Inc. + FlixBus
    Greyhound Lines, Inc. + FlixBus
    Vehicle: BusDuration:
  • Departure time: July 25 at
    Departure city: Wilmington
    Departure location: Newark (DE)
    Arrival time: July 26 at
    Destination city: Florence
    Destination location: Florence, SC
    Operated by: FlixBusFlixBus
    Vehicle: BusDuration:
  • Departure time: July 25 at
    Departure city: Wilmington
    Departure location: Newark (DE)
    Arrival time: July 26 at
    Destination city: Florence
    Destination location: Bus station
    Operated by: FlixBus + Greyhound Lines, Inc.
    FlixBus + Greyhound Lines, Inc.
    Vehicle: BusDuration:

Last refresh of the prices: Last Friday at 1:12 PM EDT.

Prices and availability are subject to change.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from Wilmington to Florence

Bus
Average PriceUS$45 - US$174Average Duration15h 40m
18kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average PriceUS$141 - US$312Average Duration10h 1m
66kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the train from Wilmington to Florence

Among the sustainable travel choices, the train stands out as a good way to reach Florence. The journey takes about 10 hours 1 minute, and with fares starting at just US$141, it presents an excellent value for a comfortable ride.

2train per day
10h 1mAverage Duration
US$141Cheapest ticket
66kgCO₂ emissions

Bus Wilmington, DE to Florence, SC, US: Trip Overview

Average Ticket PriceUS$99
Average Bus Trip Duration15h 40m
Number of daily buses2
Earliest bus departure11:20am
Distance705 km
Latest bus departure9:25pm

Wilmington to Florence Bus

Busbud helps you find a bus from Wilmington to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from Wilmington to Florence will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Wilmington to Florence, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip Wilmington, DE - Florence, SC, US

  1. How far is Wilmington from Florence?

    Wilmington and Florence are 714 km (443 miles) apart.

  2. What are the departure and arrival locations for buses traveling from Wilmington to Florence?

    Buses departing from Wilmington Bus Station in Wilmington will take you to Florence Bus Station in Florence.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
07-20
US$121
07-21
No data
Today
No data
07-23
No data
07-24
No data
07-25
US$84
07-26
No data
07-27
No data
busbud logoThe cheapest trip from Wilmington, DE to Florence, SC, US was searched and found on Jul 25, 2025 with a price of US$84

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Wilmington, DE to Florence, SC, US, as early as possible.

You can expect to pay from US$84 to US$167 for a bus ticket from Wilmington, DE to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$84 which is on 2025-07-25.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Wilmington and Florence!

Much more than a mere vehicle taking you from Wilmington to Florence, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Wilmington to Florence that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Wilmington to Florence while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

What's the cheapest way to go from Wilmington, DE to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Wilmington, DE by bus?

Bus from Wilmington, DE to Florence, SC, US

You can also go to Florence, SC, US by train

Train from Wilmington, DE to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting Wilmington

Buses Leaving from Wilmington

Buses Going to Wilmington

Popular Buses Connecting Florence

Buses Leaving from Florence

Buses Going to Florence