Bus Tickets from San Diego, CA, US to Santa Clara, US

Next departures

Next departures for San Diego to Santa Clara on October 18
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Amtrak
Santa Fe Depot
Great America StationCheapestFastest
Amtrak
Santa Fe Depot
Santa Clara Transit CenterNo tags

Last refresh of the prices: Yesterday at 12:27 PM PDT.

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Frequently asked questions on the trip San Diego, CA, US - Santa Clara, US

  1. What is the distance between San Diego and Santa Clara?

    San Diego and Santa Clara are 677 km (420 miles) apart.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-15
US$108
10-16
US$108
Today
US$108
10-18
US$108
10-19
US$108
10-20
US$108
10-21
US$108
10-22
US$108
busbud logoThe cheapest trip from San Diego, CA, US to Santa Clara, US was searched and found on Oct 15, 2025 with a price of US$108

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Clara, US, as early as possible.

You can expect to pay from US$108 to US$109 for a bus ticket from San Diego, CA, US to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$108 which is on 2025-10-18.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Diego to Santa Clara.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from San Diego to Santa Clara, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Diego to Santa Clara will emit less CO2 than a car or an airplane.

Make a music playlist for your bus ride from San Diego to Santa Clara, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Diego, CA, US by bus?

Bus from Santa Clara, US to San Diego, CA, US

You can also go to Santa Clara, US by train

Train from San Diego, CA, US to Santa Clara, US

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