Find coaches from San Diego, CA, US to Santa Clara, US

Next departures

Next departures from San Diego to Santa Clara on 19 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Amtrak
Santa Fe Depot
Great America StationCheapest
Amtrak
Santa Fe Depot
Santa Clara Transit CenterFastest

Last refresh of the prices: Last Thursday at 12:27 PDT.

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Frequently asked questions on the trip San Diego, CA, US - Santa Clara, US

  1. What's the distance between San Diego and Santa Clara by coach?

    The journey from San Diego to Santa Clara by coach covers an approximate distance of 420 miles (677 km).

  2. What is the best way to go from San Diego to Santa Clara without flying?

    To travel from San Diego to Santa Clara without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
16/10
US$108
17/10
US$108
Today
US$108
19/10
US$108
20/10
US$108
21/10
US$108
22/10
US$108
23/10
US$108
busbud logoThe cheapest trip from San Diego, CA, US to Santa Clara, US was searched and found on 16 Oct 2025 with a price of US$108

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Santa Clara, US as early as possible.

You can expect to pay from US$108 to US$109 for a bus ticket from San Diego, CA, US to Santa Clara, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$108, which is on 2025-10-19.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from San Diego to Santa Clara.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from San Diego to Santa Clara, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have the smallest carbon footprint of all motorized transport modes. A bus going from San Diego to Santa Clara will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

Make a music playlist for your bus ride from San Diego to Santa Clara, and enjoy the scenery to tunes from your own personal soundtrack.

Did you know?

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

Will you be returning to San Diego, CA, US by bus?

Bus from Santa Clara, US to San Diego, CA, US

You can also go to Santa Clara, US by train

Train from San Diego, CA, US to Santa Clara, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

People from around the world trust Busbud

‌

Popular Buses Connecting San Diego

Buses Leaving from San Diego

Buses Going to San Diego

Popular Buses Connecting Santa Clara

Buses Leaving from Santa Clara

Buses Going to Santa Clara