Bus Tickets from St. Louis to Columbus, OH

Next departures

Next departures for St. Louis to Columbus on October 8
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc.
Gateway Station
Columbus (E Mound St)CheapestFastest
Greyhound Lines, Inc.
Gateway Station
Columbus (E Mound St)No tags
Greyhound Lines, Inc.
Gateway Station
Columbus (E Mound St)No tags

Last refresh of the prices: Today at 12:59 PM CDT.

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Bus St. Louis to Columbus, OH: Trip Overview

Average Ticket PriceUS$68
Average Bus Trip Duration11h 20m
Number of daily buses3
Earliest bus departure2:00am
Distance638 km
Latest bus departure11:30pm

St. Louis to Columbus Bus

With Busbud, comparing and booking tickets for a bus from St. Louis to Columbus is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

Bus service from St. Louis to Columbus will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from St. Louis to Columbus, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip St. Louis - Columbus, OH

  1. What is the distance between St. Louis and Columbus?

    It's about 638 km (396 miles) from St. Louis to Columbus.

  2. What are the departure and arrival locations for buses traveling from St. Louis to Columbus?

    Buses traveling this route start their trip at Gateway Station, in St. Louis, and end it at Columbus Bus Station, in Columbus.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-05
US$60
10-06
No data
Today
No data
10-08
US$55
10-09
No data
10-10
No data
10-11
No data
10-12
No data
busbud logoThe cheapest trip from St. Louis to Columbus, OH was searched and found on Oct 8, 2025 with a price of US$55

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from St. Louis to Columbus, OH, as early as possible.

You can expect to pay from US$55 to US$135 for a bus ticket from St. Louis to Columbus, OH based on the last 2 days. You can expect to find the cheapest price for the trip at US$55 which is on 2025-10-08.

About Bus Travel

Bus Travel Tips

Meet and talk to locals at the bus stations while travelling from St. Louis to Columbus.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

Much more than a mere vehicle taking you from St. Louis to Columbus, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from St. Louis to Columbus that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from St. Louis to Columbus while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to St. Louis by bus?

Bus from Columbus, OH to St. Louis

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