Find coaches from San Diego, CA, US to St. Louis

Next departures

Next departures from San Diego to St. Louis on 15 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
Downtown SD (Seaport)
Gateway StationCheapest
FlixBus + Greyhound Lines, Inc.
UCSD Health La Jolla Station
Gateway StationFastest
FlixBus + Greyhound Lines, Inc.
San Diego (Old Town-FlixBus)
Gateway StationNo tags
Greyhound Lines, Inc.
Greyhound Bus Stop
Gateway StationNo tags
FlixBus + Greyhound Lines, Inc.
San Diego (Old Town-FlixBus)
Gateway StationNo tags

Last refresh of the prices: Yesterday at 02:41 PDT.

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Bus San Diego, CA, US to St. Louis: Trip Overview

Average ticket priceUS$211
Average bus trip duration1d 21h
Number of daily buses9
Earliest bus departure06:45
Distance1551 miles
Latest bus departure19:35

San Diego to St. Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Diego to St. Louis.

We make sure you can find a bus service from San Diego to St. Louis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from San Diego to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - St. Louis

  1. What's the distance between San Diego and St. Louis by coach?

    The distance between San Diego and St. Louis by coach is approximately 1560 miles (2516 km).

  2. How can I travel from San Diego to St. Louis avoiding air travel?

    You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
12/10
US$342
13/10
US$377
Today
US$269
15/10
US$207
16/10
No data
17/10
No data
18/10
No data
19/10
No data
busbud logoThe cheapest trip from San Diego, CA, US to St. Louis was searched and found on 15 Oct 2025 with a price of US$207

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to St. Louis as early as possible.

You can expect to pay from US$207 to US$377 for a bus ticket from San Diego, CA, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$207, which is on 2025-10-15.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Diego to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to St. Louis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to St. Louis that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to San Diego, CA, US by bus?

Bus from St. Louis to San Diego, CA, US

You can also go to St. Louis by train

Train from San Diego, CA, US to St. Louis

Why choose Busbud?

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Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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