Bus Tickets from San Diego, CA, US to St. Louis

Next departures

Next departures for San Diego to St. Louis on October 14
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
UCSD Health La Jolla Station
Gateway StationCheapestFastest
FlixBus + Greyhound Lines, Inc.
San Diego (Old Town-FlixBus)
Gateway StationNo tags
Greyhound Lines, Inc.
Greyhound Bus Stop
Gateway StationNo tags
FlixBus + Greyhound Lines, Inc.
San Diego (Old Town-FlixBus)
Gateway StationNo tags
FlixBus + Greyhound Lines, Inc.
UCSD Health La Jolla Station
Gateway StationNo tags

Last refresh of the prices: Today at 2:41 AM PDT.

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Bus San Diego, CA, US to St. Louis: Trip Overview

Average Ticket PriceUS$170
Average Bus Trip Duration2d
Number of daily buses11
Earliest bus departure6:45am
Distance2514 km
Latest bus departure7:35pm

San Diego to St. Louis Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from San Diego to St. Louis.

We make sure you can find a bus service from San Diego to St. Louis from the most reliable bus companies operating this trip.

From cheap bus tickets to more luxurious buses travelling from San Diego to St. Louis, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Frequently asked questions on the trip San Diego, CA, US - St. Louis

  1. How far is San Diego from St. Louis?

    The distance covered from San Diego to St. Louis is 2516 km (1560 miles).

  2. What are the departure and arrival locations for buses traveling from San Diego to St. Louis?

    Buses traveling this route start their trip at Mission Valley Sheraton, in San Diego, and end it at Gateway Station, in St. Louis.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10-11
US$364
10-12
US$342
Today
US$377
10-14
US$269
10-15
US$207
10-16
No data
10-17
No data
10-18
No data
busbud logoThe cheapest trip from San Diego, CA, US to St. Louis was searched and found on Oct 15, 2025 with a price of US$207

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to St. Louis, as early as possible.

You can expect to pay from US$207 to US$377 for a bus ticket from San Diego, CA, US to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at US$207 which is on 2025-10-15.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from San Diego to St. Louis but it'll also be endearing to native speakers who will surely appreciate your effort.

Start sightseeing the minute your bus leaves the station. If you're on the night bus from San Diego to St. Louis, get comfy and count the stars.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to St. Louis that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from San Diego to St. Louis while indulging in miles on end of beautiful scenic views.

Did you know?

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to San Diego, CA, US by bus?

Bus from St. Louis to San Diego, CA, US

You can also go to St. Louis by train

Train from San Diego, CA, US to St. Louis

Why choose Busbud?

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